Specifically, I'd love it if Control-W shortcut to close the program had some way to back out of it. Because of other triggers I've set and am very accustomed to, it is way too easy to trigger this shortcut and tab to the "Don't Save" button and hit enter, which I did this morning, losing some unsaved work.

I'd just rather never have this particular function on shortcut.

If disabling is not an option, how about allowing the shortcut to remain in the system, but remap the trigger to a combination less likely to be inadvertently hit?